Pair Name | Beta-Elemene, Gefitinib | ||
Phytochemical Name | Beta-Elemene (PubChem CID: 6918391 ) | ||
Anticancer drug Name | Gefitinib (PubChem CID: 123631 ) | ||
Structure of Phytochemical |
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Structure of Anticancer Drug |
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Pair Name | Beta-Elemene, Gefitinib | |||
Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
Biological Phenomena | Inhibition-->Epithelial-mesenchymal transition | |||
Gene Regulation | Up-regulation | Expression | CDH1 | hsa999 |
Down-regulation | Expression | CDH2 | hsa1000 | |
Up-regulation | Expression | HES1 | hsa3280 | |
Up-regulation | Expression | MYC | hsa4609 | |
Up-regulation | Expression | NOTCH1 | hsa4851 | |
Up-regulation | Expression | SHH | hsa6469 | |
Down-regulation | Expression | SNAI1 | hsa6615 | |
Up-regulation | Expression | SOX2 | hsa6657 | |
Down-regulation | Expression | TWIST1 | hsa7291 | |
Down-regulation | Expression | VIM | hsa7431 | |
Down-regulation | Expression | ZEB1 | hsa6935 | |
In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 | |
Result | The findings may have potential implications for treating aggressive and resistant lung cancers. |
No. | Title | Href |
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1 | β-Elemene Synergizes With Gefitinib to Inhibit Stem-Like Phenotypes and Progression of Lung Cancer via Down-Regulating EZH2. Front Pharmacol. 2018 Nov 30;9:1413. doi: 10.3389/fphar.2018.01413. | Click |