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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Beta-Elemene, Gefitinib
Phytochemical Name Beta-Elemene (PubChem CID: 6918391 )
Anticancer drug Name Gefitinib (PubChem CID: 123631 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 708
Pair Name Beta-Elemene, Gefitinib
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Inhibition-->Epithelial-mesenchymal transition
Gene Regulation Up-regulation Expression CDH1 hsa999
Down-regulation Expression CDH2 hsa1000
Up-regulation Expression HES1 hsa3280
Up-regulation Expression MYC hsa4609
Up-regulation Expression NOTCH1 hsa4851
Up-regulation Expression SHH hsa6469
Down-regulation Expression SNAI1 hsa6615
Up-regulation Expression SOX2 hsa6657
Down-regulation Expression TWIST1 hsa7291
Down-regulation Expression VIM hsa7431
Down-regulation Expression ZEB1 hsa6935
In Vitro Model A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
NCI-H1299 Lung large cell carcinoma Homo sapiens (Human) CVCL_0060
Result The findings may have potential implications for treating aggressive and resistant lung cancers.
03. Reference
No. Title Href
1 β-Elemene Synergizes With Gefitinib to Inhibit Stem-Like Phenotypes and Progression of Lung Cancer via Down-Regulating EZH2. Front Pharmacol. 2018 Nov 30;9:1413. doi: 10.3389/fphar.2018.01413. Click
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